Etomoxir Sodium Salt Promotes Imidazole Ketone Erastin-Induced Myeloid-Derived Suppressor Cell Ferroptosis and Enhances Cancer Therapy
Nada Mohamady Farouk Abdalsalam, Zihao Liang, Hafiza Kashaf Tariq, Abdulrahman Ibrahim, Rong Li, Xiaochun Wan, Dehong Yan · 2024
Read Etomoxir Sodium Salt Promotes Imidazole Ketone Erastin-Induced Myeloid-Derived Suppressor Cell Ferroptosis and Enhances Cancer Therapy by Nada Mohamady Farouk Abdalsalam, Zihao Liang, Hafiza Kashaf Tariq, Abdulrahman Ibrahim, Rong Li, Xiaochun Wan, Dehong Yan (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11592117.txt.
Description
Nada Mohamady Farouk Abdalsalam and co-authors test a two-drug combo against suppressor cells that shield tumors in this 2024 paper. A ferroptosis-inducing drug kills tumor cells but fails alone, because myeloid suppressor cells protect the tumor. A second drug blocks a fat-burning enzyme those cells rely on.
Together, the drugs pushed the suppressor cells themselves into ferroptosis, an iron-driven cell death. The combo lowered the cells' defense proteins and cut their buildup in tumors. Freed from suppression, T cells multiplied and entered tumor tissue more strongly. Tumor therapy improved as a result. The authors argue the pairing deserves clinical testing. They frame it as a way to turn a shield cell into a target.
Catalog record
| CREATOR | Nada Mohamady Farouk Abdalsalam, Zihao Liang, Hafiza Kashaf Tariq, Abdulrahman Ibrahim, Rong Li, Xiaochun Wan, Dehong Yan |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |