Stannous Chloride-Modified Glass Substrates for Biomolecule Immobilization: Development of Label-Free Interferometric Sensor Chips for Highly Sensitive Detection of Aflatoxin B1 in Corn
Alexey V Orlov, Maria O Zolotova, Denis O Novichikhin, Nikolai A Belyakov, Svetlana G Protasova, Petr I Nikitin, Artem V Sinolits · 2024
Read Stannous Chloride-Modified Glass Substrates for Biomolecule Immobilization: Development of Label-Free Interferometric Sensor Chips for Highly Sensitive Detection of Aflatoxin B1 in Corn by Alexey V Orlov, Maria O Zolotova, Denis O Novichikhin, Nikolai A Belyakov, Svetlana G Protasova, Petr I Nikitin, Artem V Sinolits (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11591935.txt.
Description
Alexey Orlov and co-authors built a cheap glass chip that sniffs out a potent corn toxin, in a 2024 paper. Aflatoxin B1, made by a common mold, causes cancer at trace levels, so food testing needs extreme sensitivity without labels or dyes. Their trick treats glass with stannous chloride, giving proteins a firm grip. Tuned recipes fixed the dose, time, and drying heat for the coating.
On that glass, an interferometric sensor running a competitive immunoassay detected the toxin down to twenty-six picograms per milliliter, across five orders of magnitude. Spiked real corn flour samples validated the readings. The substrate could host many other sensors, the authors argue.
Catalog record
| CREATOR | Alexey V Orlov, Maria O Zolotova, Denis O Novichikhin, Nikolai A Belyakov, Svetlana G Protasova, Petr I Nikitin, Artem V Sinolits |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |