Propafenone facilitates mitochondrial-associated ferroptosis and synergizes with immunotherapy in melanoma
Qian Zhou, Yating Dian, Yi He, Lei Yao, Hui Su, Yu Meng, Yuming Sun, Daishi Li, Yixiao Xiong, Furong Zeng, Xiaowei Liang, Hong Liu, Xiang Chen, Guangtong Deng · 2024
Read Propafenone facilitates mitochondrial-associated ferroptosis and synergizes with immunotherapy in melanoma by Qian Zhou, Yating Dian, Yi He, Lei Yao, Hui Su, Yu Meng, Yuming Sun, Daishi Li, Yixiao Xiong, Furong Zeng, Xiaowei Liang, Hong Liu, Xiang Chen, Guangtong Deng (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11590812.txt.
Description
Qian Zhou and co-authors find that a heart rhythm drug can push melanoma cells into an iron-driven death and boost immune therapy, in a 2024 study. Melanoma often resists immune checkpoint drugs, and triggering ferroptosis, a death by iron and fat oxidation, may reopen the door. The team screened two hundred approved cardiovascular drugs for one that sensitises cells to that death.
The winner was propafenone. Paired with a standard ferroptosis trigger, it drove death centred on the mitochondria, the cell power stations. The drug switched on a stress pathway that raised a mitochondrial enzyme, flooding the organelle with iron and reactive oxygen. In mouse grafts, the pairing nearly wiped out tumours and extended survival. It also strengthened immune therapy in mice, and patients whose tumours showed high levels of the same pathway markers responded better to immune therapy. The authors propose the old drug for a new role.
Catalog record
| CREATOR | Qian Zhou, Yating Dian, Yi He, Lei Yao, Hui Su, Yu Meng, Yuming Sun, Daishi Li, Yixiao Xiong, Furong Zeng, Xiaowei Liang, Hong Liu, Xiang Chen, Guangtong Deng |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 74 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |