VprBP regulates osteoclast differentiation via an epigenetic mechanism involving histone H2A phosphorylation
Yonghwan Shin, Sungmin Kim, Tae-Ik Choi, Cheol-Hee Kim, Woojin An · 2024
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Description
Bone stays strong through a balance of cells that chew it down and cells that build it up. Yonghwan Shin and co-authors study a protein that tips the chewing side in a 2024 paper on bone cell growth.
The protein, VprBP, is known as a kinase that helps silence genes. The team found it pushes precursor cells to mature into bone-eating cells when a key signal arrives. It works by adding a phosphate mark to a histone protein, which shuts off genes that would block the change. Blocking that kinase power revived the blocking genes and stalled cell growth. Animal work tied the mark to low bone mass, pointing to a new drug angle for osteoporosis.
Catalog record
| CREATOR | Yonghwan Shin, Sungmin Kim, Tae-Ik Choi, Cheol-Hee Kim, Woojin An |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |