Untargeted urine metabolomics suggests that ascorbic acid may serve as a promising biomarker for reduced feed intake in rabbits
Pablo Jesús Marín-García, Miriam Piles, Juan Pablo Sánchez, Mariam Pascual, Lola Llobat, Juan José Pascual, Mette Skou Hedemann · 2024
Read Untargeted urine metabolomics suggests that ascorbic acid may serve as a promising biomarker for reduced feed intake in rabbits by Pablo Jesús Marín-García, Miriam Piles, Juan Pablo Sánchez, Mariam Pascual, Lola Llobat, Juan José Pascual, Mette Skou Hedemann (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11589781.txt.
Description
Pablo Jesús Marín-García and co-authors search rabbit urine for a chemical sign that an animal has stopped eating enough. Feed restriction is routine on rabbit farms, but a drop in eating can also warn of early digestive trouble. The team studied 48 growing rabbits from two genetic lines, comparing free feeding with a four-day period at half of maintenance needs. Urine samples from both periods went through untargeted metabolomics, a broad scan of small molecules.
The two genetic lines did not differ in their urine profiles, but restriction changed the picture sharply. Ascorbic acid rose the most clearly, alongside shifts in several sulphate compounds and other metabolites. Because the same animals were tested in both states, the changes track feeding rather than breed. The authors propose ascorbic acid as a promising early marker of reduced intake.
Catalog record
| CREATOR | Pablo Jesús Marín-García, Miriam Piles, Juan Pablo Sánchez, Mariam Pascual, Lola Llobat, Juan José Pascual, Mette Skou Hedemann |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |