Macrophage tracking with USPIO imaging and T2 mapping predicts immune rejection of transplanted stem cells
Wenhui Wang, Zhenyu Liu, Jiahong Zhu, Haocheng Zhen, Meiling Qi, Jing Luo, Junping Zhen · 2024
Read Macrophage tracking with USPIO imaging and T2 mapping predicts immune rejection of transplanted stem cells by Wenhui Wang, Zhenyu Liu, Jiahong Zhu, Haocheng Zhen, Meiling Qi, Jing Luo, Junping Zhen (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11589617.txt.
Description
Wenhui Wang and co-authors use MRI scans to watch immune cells move toward stem cell grafts in rabbit knees, in a 2024 study. Stem cells can mend worn cartilage, but the body may reject them. Macrophages, a front-line immune cell, flood a graft site when rejection brews. If scans could count them, doctors could spot trouble with no biopsy.
The team loaded 32 rabbits with tiny iron particles that macrophages swallow. After knee defects and grafts of varied stem cell types, scans tracked a signal tied to cell counts in tissue checks. Fat-derived cells provoked stronger rejection than bone marrow cells. Cells from another species drew the longest rejection. The signal map predicted macrophage density well in the defect. The authors offer the scan method as a tool for watching graft safety.
Catalog record
| CREATOR | Wenhui Wang, Zhenyu Liu, Jiahong Zhu, Haocheng Zhen, Meiling Qi, Jing Luo, Junping Zhen |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |