Exploring the Role of Adipose Tissue Dysregulation in Vitiligo Pathogenesis: A Body Composition Analysis
XinYi SHAO, Xingyu PAN, Tingqiao CHEN, Ziyan CHEN, Yuhao LI, Judan ZHONG, Ruiyao WANG, Jun YU, Jin CHEN, Yangmei CHEN · 2024
Read Exploring the Role of Adipose Tissue Dysregulation in Vitiligo Pathogenesis: A Body Composition Analysis by XinYi SHAO, Xingyu PAN, Tingqiao CHEN, Ziyan CHEN, Yuhao LI, Judan ZHONG, Ruiyao WANG, Jun YU, Jin CHEN, Yangmei CHEN (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11589468.txt.
Description
Vitiligo is a skin disease in which pigment cells are destroyed, leaving pale patches, and the role of body fat in the disease is unclear. The ten authors enrolled 50 newly diagnosed patients and 40 matched healthy controls. They measured fat mass and its spread with dual-energy X-ray scans and checked blood levels of fat-linked hormones called adipokines. Patients carried more trunk and whole-body fat, and a higher trunk-to-limb fat ratio, than controls.
Patients also had higher leptin and resistin and lower adiponectin. Trunk fat tracked with the vitiligo area score, and adiponectin fell as disease activity rose. Several fat measures separated patients from controls well in curve analysis. The authors conclude that central obesity and adipokine imbalance are more common in vitiligo, and they argue the role of fat tissue in the disease deserves more weight.
Catalog record
| CREATOR | XinYi SHAO, Xingyu PAN, Tingqiao CHEN, Ziyan CHEN, Yuhao LI, Judan ZHONG, Ruiyao WANG, Jun YU, Jin CHEN, Yangmei CHEN |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |