Genetic insights into blood protein correlations with colorectal cancer: a Mendelian randomization study
Wenjing Xu, Wei Li, Yaqiang Li, Dayu Kuai, Wei Sun, Xian Liu, Baohong Xu · 2024
Read Genetic insights into blood protein correlations with colorectal cancer: a Mendelian randomization study by Wenjing Xu, Wei Li, Yaqiang Li, Dayu Kuai, Wei Sun, Xian Liu, Baohong Xu (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11589031.txt.
Description
Wenjing Xu and co-authors use genetics to test whether proteins in the blood help cause bowel cancer. Studies that just watch people can be skewed by lifestyle and illness, so the team leaned on gene variants as natural experiments. Data covered nearly fifteen hundred blood proteins and bowel cancer records from over six hundred thousand people.
Eight proteins cleared the team's screens. Three of them raised cancer risk, while the other five lowered it. Checks for stray pathways came back clean, and the links held after accounting for weight, diabetes, and smoking in the models. The findings hand drug researchers a short list of blood proteins whose causal role in bowel cancer now has genetic backing.
Catalog record
| CREATOR | Wenjing Xu, Wei Li, Yaqiang Li, Dayu Kuai, Wei Sun, Xian Liu, Baohong Xu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 30 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |