Insights into durability against resistance from the antibiotic nitrofurantoin
Riannah Kettlewell, Charlotte Jones, Timothy W Felton, Mato Lagator, Danna R Gifford · 2024
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Description
Riannah Kettlewell, Charlotte Jones, Timothy Felton, Mato Lagator, and Danna Gifford ask why one antibiotic has resisted resistance in this 2024 paper. Nitrofurantoin has treated infections for over seventy years, yet bacteria have barely learned to beat it, a rare record among antibiotics.
The authors credit a stack of features. The drug reaches working levels fast and hits bacteria at several physiological targets at once. Resistance genes spread poorly between bacteria, and a cell needs several mutations at once to withstand the drug. Together these traits choke off both the birth and the travel of resistance. The team proposes the drug as a model for designing other treatments built to last.
Catalog record
| CREATOR | Riannah Kettlewell, Charlotte Jones, Timothy W Felton, Mato Lagator, Danna R Gifford |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |