Core Concepts in Pharmacoepidemiology: New‐User Designs
Qoua L. Her, Julie Rouette, Jessica C. Young, Michael Webster‐Clark, John Tazare · 2024
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Description
Qoua Her, Julie Rouette, Jessica Young, Michael Webster-Clark, and John Tazare explain a core design choice in drug safety research, in a 2024 methods paper. Studies that use health records can go wrong if they compare people who just started a drug with people who have taken it for years. New-user designs avoid that trap by starting the clock at the first prescription.
The authors walk through three versions of the design: new users against non-users, new users against new users of a rival drug, and a variant for people switching drugs. A worked example on hormone therapy and heart disease shows the trade-offs in practice. Each version sets its start time and comparison group with care. The guide helps researchers pick the design that fits their question.
Catalog record
| CREATOR | Qoua L. Her, Julie Rouette, Jessica C. Young, Michael Webster‐Clark, John Tazare |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 35 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |