The shared genetic landscape of polycystic ovary syndrome and breast cancer: convergence on ER + breast cancer but not ER- breast cancer
Kaixin Bi, Miaoran Chen, Qianru Zhao, Tongtong Yang, Wenjia Xie, Wenqi Ma, Hongyan Jia · 2024
Read The shared genetic landscape of polycystic ovary syndrome and breast cancer: convergence on ER + breast cancer but not ER- breast cancer by Kaixin Bi, Miaoran Chen, Qianru Zhao, Tongtong Yang, Wenjia Xie, Wenqi Ma, Hongyan Jia (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11587662.txt.
Description
Kaixin Bi and co-authors mapped shared genes between two women's diseases in a 2024 study. Polycystic ovary syndrome and breast cancer strike the same patients more often than chance allows. Whether that pairing rests on shared genes, and not just shared life traits, was not known.
The team ran genome-wide cross-trait tests on the largest gene study data to date. Overlap showed up for the syndrome with breast cancer as a whole. When the cancer split by hormone response, the link held for the hormone-positive form but not the other. That split hints at which care and screening paths the two diseases may share.
Catalog record
| CREATOR | Kaixin Bi, Miaoran Chen, Qianru Zhao, Tongtong Yang, Wenjia Xie, Wenqi Ma, Hongyan Jia |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |