FCGBP functions as a tumor suppressor gene in head and neck squamous cell carcinoma
Lijuan Zeng, Jun Zeng, Jianfeng He, Yongqi Li, Chengwei Li, Zhiyan Lin, Guangwei Chen, Huilin Wu, Libin Zhou · 2024
Read FCGBP functions as a tumor suppressor gene in head and neck squamous cell carcinoma by Lijuan Zeng, Jun Zeng, Jianfeng He, Yongqi Li, Chengwei Li, Zhiyan Lin, Guangwei Chen, Huilin Wu, Libin Zhou (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11586324.txt.
Description
Lijuan Zeng and colleagues make the case that a little-known mucus protein acts as a brake on head and neck cancer, in this study from twenty twenty-four. The protein, FCGBP, was lower in tumors than in healthy tissue across several large datasets, and patients whose tumors kept more of it lived longer. It held up as an independent survival marker in a validation cohort.
Experiments gave the correlation a mechanism. Silencing the gene in two cancer cell lines made the cells migrate and invade more aggressively. It also tilted the immune neighborhood: fewer killer T cells, more suppressor cells. Genes traveling with FCGBP clustered in immune processes, as if its presence keeps the anti-tumor response switched on. The authors name it a tumor suppressor and a candidate for monitoring and drug development.
Catalog record
| CREATOR | Lijuan Zeng, Jun Zeng, Jianfeng He, Yongqi Li, Chengwei Li, Zhiyan Lin, Guangwei Chen, Huilin Wu, Libin Zhou |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |