Causal Effects of Rheumatoid Arthritis, Ankylosing Spondylitis, Juvenile Idiopathic Arthritis on Psoriasis: A Mendelian Randomization Study
Yongping Cao, Mengyun Zhou, Tianhong Xu · 2024
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Description
Yongping Cao, Mengyun Zhou, and Tianhong Xu report a 2024 study on whether three joint diseases cause a scaly skin disease. The three diseases attack joints in adults and in children, and the skin disease often shows up near their diagnosis. Shared genes may drive both, which a gene-based method can test without a trial.
The team drew gene data from a large open bank for all four diseases. Single-disease checks found causal links from each of the three joint diseases to the skin disease. Checks for bias and noise backed those finds. A joint check that weighed all three at once kept two as risk factors, while the adult joint disease lost its effect. The work adds to grasp of how the skin disease starts.
Catalog record
| CREATOR | Yongping Cao, Mengyun Zhou, Tianhong Xu |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 29 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |