Expression of senescence-related CD161 promotes extranodal NK/T cell lymphoma by affecting T cell phenotype and cell cycle
Chengxun Jin, Xin Li, Chaohe Zhang · 2024
Read Expression of senescence-related CD161 promotes extranodal NK/T cell lymphoma by affecting T cell phenotype and cell cycle by Chengxun Jin, Xin Li, Chaohe Zhang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11585959.txt.
Description
Chengxun Jin, Xin Li, and Chaohe Zhang wrote this 2024 study on a gene called CD161 and its role in a rare lymphoma of natural killer and T cells. The gene is tied to cell aging, and this cancer is aggressive. The team built aging models of three cancer cell lines with peroxide and tracked how the cells changed.
Aged cells raised two marker proteins of aging and stalled in the first growth phase. One T cell marker and CD161 itself rose, while a killer cell marker fell. Gene reads found 2,843 genes that shifted with aging. Mouse tumors grown from aged cells were also checked. The study sets up the claim in its title: aging-linked CD161 helps drive this lymphoma by reshaping cell type and the cell cycle.
Catalog record
| CREATOR | Chengxun Jin, Xin Li, Chaohe Zhang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |