Association of serum HIF-1α levels with coronary artery calcification in patients of non-dialysis chronic kidney disease
Congcong Qin, Zhijuan Hu, Yanan Shi, Haowen Wu, Jingyu Ma, Jing Li · 2024
Read Association of serum HIF-1α levels with coronary artery calcification in patients of non-dialysis chronic kidney disease by Congcong Qin, Zhijuan Hu, Yanan Shi, Haowen Wu, Jingyu Ma, Jing Li (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11585538.txt.
Description
Congcong Qin, Zhijuan Hu, Yanan Shi, Haowen Wu, Jingyu Ma, and Jing Li examine a blood protein as an early warning sign for clogged heart arteries in kidney patients. Vascular calcification is the main killer in chronic kidney disease. The team studied 123 patients whose kidney disease had not reached dialysis. They measured levels of hypoxia-inducible factor 1-alpha, a protein cells make when oxygen runs low, against calcium scores for their coronary arteries.
Patients with calcification were older, more often male, and had higher levels of the protein. As protein levels rose, the share of patients with calcification and their calcium scores climbed. Statistical modeling flagged older age, male sex, and higher protein levels as risk factors. A protein cut-off identified calcification with about sixty-six percent sensitivity and eighty-one percent specificity. The authors say the marker carries useful diagnostic value for this group.
Catalog record
| CREATOR | Congcong Qin, Zhijuan Hu, Yanan Shi, Haowen Wu, Jingyu Ma, Jing Li |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |