Transcriptomic, mutational and structural bioinformatics approaches to explore the therapeutic role of FAP in predominant cancer types
Gayathri Ashok, Abdullah F. AlAsmari, Fawaz AlAsmari, Paul Livingstone, Anand Anbarasu, Sudha Ramaiah · 2024
Read Transcriptomic, mutational and structural bioinformatics approaches to explore the therapeutic role of FAP in predominant cancer types by Gayathri Ashok, Abdullah F. AlAsmari, Fawaz AlAsmari, Paul Livingstone, Anand Anbarasu, Sudha Ramaiah (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11585531.txt.
Description
A surface mark on scar like cells in tumours can help cancers grow, and it may serve as a drug target. Gayathri Ashok and co-authors scan that mark, called FAP, across cancer types in a 2024 study. They join gene reads, change hunts, and shape sims in one sweep.
The sims showed the mark holds a steady shape, with low wobble in its back bone. Five changes in its cut zone stood out as apt to harm its work. Screen tests then sifted drug like bits for ones that grip the mark hard. One lead bit gripped best and sat right on the mark's three key cut spots. Its hold stayed firm in sims. The team puts the lead forth for lab tests.
Catalog record
| CREATOR | Gayathri Ashok, Abdullah F. AlAsmari, Fawaz AlAsmari, Paul Livingstone, Anand Anbarasu, Sudha Ramaiah |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |