Tumor analysis of BRCA carriers reveals genomic similarities although separated by time
Tal Falick Michaeli, Avital Granit Mizrahi, Batia Azria, Ofra Maymon, Shai Rosenberg, Jonathan Monin, Esther Braitbart Cohen, Myriam Maoz, Luna Kadiuri, Hovav Nechushtan, Amichay Meyrowitz, Tamar Peretz · 2024
Read Tumor analysis of BRCA carriers reveals genomic similarities although separated by time by Tal Falick Michaeli, Avital Granit Mizrahi, Batia Azria, Ofra Maymon, Shai Rosenberg, Jonathan Monin, Esther Braitbart Cohen, Myriam Maoz, Luna Kadiuri, Hovav Nechushtan, Amichay Meyrowitz, Tamar Peretz (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11585525.txt.
Description
Tal Falick Michaeli and co-authors compared tumors that arose years apart in the same BRCA carriers, in a 2024 study. BRCA gene faults strongly raise breast cancer risk and shape treatment choices. A fair question is how much a tumor's profile comes from the inherited fault versus later life exposures. Comparing two tumors in one patient cancels the rest of the inherited background.
Three women each had two separate primary breast cancers studied, and two also had a lung cancer. Tumors from the same tissue in the same woman looked molecularly alike despite the years between them. That held even though each woman met many outside influences in the gap. Early-life marks that persist in the body may help explain the likeness. The study is small, but it sharpens how doctors think about second cancers.
Catalog record
| CREATOR | Tal Falick Michaeli, Avital Granit Mizrahi, Batia Azria, Ofra Maymon, Shai Rosenberg, Jonathan Monin, Esther Braitbart Cohen, Myriam Maoz, Luna Kadiuri, Hovav Nechushtan, Amichay Meyrowitz, Tamar Peretz |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 24 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |