Genome-wide methylation profiling differentiates benign from aggressive and metastatic pituitary neuroendocrine tumors
Jelena Jotanovic, Henning Bünsow Boldt, Mark Burton, Marianne Skovsager Andersen, Daniel Bengtsson, Thomas Olsson Bontell, Bertil Ekman, Britt Edén Engström, Ulla Feldt-Rasmussen, Ansgar Heck, Antonia Jakovcevic, Jens Otto L. Jørgensen, Ivana Kraljevic, Jacek Kunicki, John R. Lindsay, Marco Losa, Pa · 2024
Read Genome-wide methylation profiling differentiates benign from aggressive and metastatic pituitary neuroendocrine tumors by Jelena Jotanovic, Henning Bünsow Boldt, Mark Burton, Marianne Skovsager Andersen, Daniel Bengtsson, Thomas Olsson Bontell, Bertil Ekman, Britt Edén Engström, Ulla Feldt-Rasmussen, Ansgar Heck, Antonia Jakovcevic, Jens Otto L. Jørgensen, Ivana Kraljevic, Jacek Kunicki, John R. Lindsay, Marco Losa, Pa (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11585505.txt.
Description
Jelena Jotanovic led a large team profiling DNA methylation in pituitary tumors in a 2024 paper. A small share of these tumors grow aggressively despite all standard treatment, and some spread to distant sites. Markers to spot them early are scarce because the tumors are rare. The team analyzed tumor tissue from dozens of aggressive and metastatic cases plus a small benign comparison group.
Unsupervised grouping separated aggressive and spreading tumors from benign ones by their methylation patterns. Copy-number changes riddled the aggressive genomes while benign tumors stayed mostly clean. The authors say methylation profiling could help flag dangerous tumors sooner.
Catalog record
| CREATOR | Jelena Jotanovic, Henning Bünsow Boldt, Mark Burton, Marianne Skovsager Andersen, Daniel Bengtsson, Thomas Olsson Bontell, Bertil Ekman, Britt Edén Engström, Ulla Feldt-Rasmussen, Ansgar Heck, Antonia Jakovcevic, Jens Otto L. Jørgensen, Ivana Kraljevic, Jacek Kunicki, John R. Lindsay, Marco Losa, Pa |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 57 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |