Comparison of the Cecum Ligation and Puncture Method and the Intraperitoneal Lipopolysaccharide Injection Method for the Construction of a New-Onset Atrial Fibrillation Model of Sepsis
Xiuwen Ling, Jun Shen, Junqing Liang, Kai Yang, Jianzhong Yang · 2024
Read Comparison of the Cecum Ligation and Puncture Method and the Intraperitoneal Lipopolysaccharide Injection Method for the Construction of a New-Onset Atrial Fibrillation Model of Sepsis by Xiuwen Ling, Jun Shen, Junqing Liang, Kai Yang, Jianzhong Yang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11585273.txt.
Description
Xiuwen Ling and co-authors compare two ways to build a rat model of a heart rhythm problem in sepsis in 2024. Sepsis is a severe whole-body response to infection, and a fast, uneven heartbeat often starts during it. That rhythm problem raises the risk of harm and death for patients. An animal model is needed to study how it starts. The team tried gut surgery that mimics infection and injections of a bacterial toxin at four doses.
Forty-seven rats were split across the method and dose groups. The toxin dose in the middle range gave the most stable model of the rhythm problem. Those rats showed a wider upper heart chamber, more scarring, and weaker pumping. Their hearts were easier to push into the uneven rhythm. Levels of swelling-linked proteins rose in the heart tissue. The authors name the pathways they think drive the problem.
Catalog record
| CREATOR | Xiuwen Ling, Jun Shen, Junqing Liang, Kai Yang, Jianzhong Yang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |