Dendritic cells under the control of the preimplantation embryo secretome: an in vitro study
Christiana Kyvelidou, Sofia Haselrieder, Maria von Gierke, Johanna M Gostner, Wolfgang Biasio, Barbara Wirleitner, Christine Heufler, Bettina Toth, Susanne Hofer-Tollinger · 2024
Read Dendritic cells under the control of the preimplantation embryo secretome: an in vitro study by Christiana Kyvelidou, Sofia Haselrieder, Maria von Gierke, Johanna M Gostner, Wolfgang Biasio, Barbara Wirleitner, Christine Heufler, Bettina Toth, Susanne Hofer-Tollinger (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11585248.txt.
Description
Christiana Kyvelidou and co-authors study how embryo fluids affect immune cells in a 2024 paper. Before an embryo implants, it releases a mix of molecules into its surroundings. Those signals may shape how the mother immune system responds. The team collected spent culture media from human blastocysts and tested them on dendritic cells, which help direct immune responses.
Protein tests found a wide range of cytokines and growth factors in the media. Media from embryos that failed to implant raised activation markers on the immune cells more strongly. Treated cells released low levels of cytokines yet could still activate naive T cells. A key enzyme activity fell after treatment. The authors conclude that embryos actively signal to immune cells around them.
Catalog record
| CREATOR | Christiana Kyvelidou, Sofia Haselrieder, Maria von Gierke, Johanna M Gostner, Wolfgang Biasio, Barbara Wirleitner, Christine Heufler, Bettina Toth, Susanne Hofer-Tollinger |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |