TLR4-dependent neuroinflammation mediates LPS-driven food-reward alterations during high-fat exposure
Sabrina J. P. Huwart, Clémence Fayt, Giuseppe Gangarossa, Serge Luquet, Patrice D. Cani, Amandine Everard · 2024
Read TLR4-dependent neuroinflammation mediates LPS-driven food-reward alterations during high-fat exposure by Sabrina J. P. Huwart, Clémence Fayt, Giuseppe Gangarossa, Serge Luquet, Patrice D. Cani, Amandine Everard (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11585241.txt.
Description
Sabrina Huwart and five co-authors probe how a gut germ product scrambles food reward in mice, in a 2024 study. Obesity reshapes both hunger and the pleasure side of eating. Germ products leaking from the gut can stir brain inflammation, and the team asked whether that stirring drives the reward change on a high-fat diet.
They used behavior tests tied to food seeking and drugs that target the dopamine circuit. Mice lacking a sensor for the germ product, called TLR4, were compared with normal mice. Tiny doses of the product dripped into the brain copied the inflammation pattern seen in obesity. Short high-fat feeding already nudged food seeking. The line of tests pins the reward drift on this sensor pathway.
Catalog record
| CREATOR | Sabrina J. P. Huwart, Clémence Fayt, Giuseppe Gangarossa, Serge Luquet, Patrice D. Cani, Amandine Everard |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |