Effect of Tricin on cardiomyocyte damage caused by diabetic cardiomyopathy (DCM)
Rong Yu, Yaping Zhang, Tong Wang, Jinju Duan, Xiaoming Li · 2024
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Description
Rong Yu and co-authors published this heart study in 2024. Diabetic cardiomyopathy is heart harm wrought by diabetes itself, apart from blocked vessels. The team tested tricin, a plant compound from the flavonoid family, known for fighting rust-like cell harm and swelling. They grew rat heart cells in high sugar to mimic the disease, then dosed them with the compound.
Tricin eased the harm in step with dose. Markers of cell stress fell, a guard enzyme rose, and three swelling signals dropped. A chain of proteins that drives swelling, named for its parts TLR4, MYD88, and NF-κB, quieted as well. The authors say tricin guards heart cells by damping both stress and swelling. They call for animal and clinic tests to see if the gain holds in whole hearts.
Catalog record
| CREATOR | Rong Yu, Yaping Zhang, Tong Wang, Jinju Duan, Xiaoming Li |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |