Multi-locus high-risk alleles association from interleukin’s genes with female infertility and certain comorbidities
Khalil Khashei Varnamkhasti, Samire Khashei Varnamkhasti, Najmeh Bahraini, Mohaddeseh Davoodi, Mahsa Sadeghian, Massomeh Khavanin, Raana Naeimi, Sirous Naeimi · 2024
Read Multi-locus high-risk alleles association from interleukin’s genes with female infertility and certain comorbidities by Khalil Khashei Varnamkhasti, Samire Khashei Varnamkhasti, Najmeh Bahraini, Mohaddeseh Davoodi, Mahsa Sadeghian, Massomeh Khavanin, Raana Naeimi, Sirous Naeimi (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11585211.txt.
Description
Khalil Khashei Varnamkhasti and seven co-authors hunt for infertility risk letters in immune genes in a 2024 study. Signaling proteins called interleukins help run the immune system, and spelling variants in their genes have been suspected in female infertility. The team tested eleven variants across five interleukin genes.
Five separate case-control groups were recruited, each with two hundred infertile women and two hundred fertile controls, one group per gene family. Samples were typed with a mutation-specific amplification method. Statistical checks, corrected for multiple comparisons and population structure, found risk versions at every substitution site examined. Haplotype analysis added pattern-level evidence. The authors read the sweep as support for a shared genetic thread: immune signaling variants tilt fertility odds. Replication in other populations is the natural next step before any screening use.
Catalog record
| CREATOR | Khalil Khashei Varnamkhasti, Samire Khashei Varnamkhasti, Najmeh Bahraini, Mohaddeseh Davoodi, Mahsa Sadeghian, Massomeh Khavanin, Raana Naeimi, Sirous Naeimi |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 38 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |