The impact of Radioresistant-Related Telomere Genes in the prognosis and immune infiltration in lung adenocarcinoma
Peng Li, Lu Meng, Hongbin Tu, Shilan Luo, Xiaomei Gong · 2024
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Description
Peng Li and four co-authors built a prognostic score for lung adenocarcinoma from genes tied to telomeres and radiation resistance, in a 2024 paper. Lung adenocarcinoma kills many patients, and telomere biology interacts with radiotherapy response. The team mined public datasets and their own samples, comparing gene activity in tumors and healthy tissue. They asked which of these genes track survival and immune cell presence inside tumors.
Three genes formed the core of a score that forecast survival with dependable accuracy. The team wrapped the score into nomograms, chart tools that turn it into personal risk estimates for clinic use. Genetic patterns also lined up with how much immune infiltration a tumor had, hinting at treatment implications. Lab checks confirmed the genes' levels in cell lines and tumor samples. The authors offer the score as a step toward personal prognosis.
Catalog record
| CREATOR | Peng Li, Lu Meng, Hongbin Tu, Shilan Luo, Xiaomei Gong |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |