Gut-derived IL-13 contributes to growth via promoting hepatic IGF-1 production
Ning Ma, Haolong Wang, Qiuhua Li, Mengyu Chang, Jiandi Zhu, Sha Nan, Qiulin Zhang, Qiao Li, Diqi Yang, Ke Ming, Shen Zhuang, Panpan Guo, Ruiling Yin, Jinrui Sun, Huikang Wang, Qianghui Lei, Zhenli Liu, Mingxing Ding, Xiaoshu Zhou, Yi Ding · 2024
Read Gut-derived IL-13 contributes to growth via promoting hepatic IGF-1 production by Ning Ma, Haolong Wang, Qiuhua Li, Mengyu Chang, Jiandi Zhu, Sha Nan, Qiulin Zhang, Qiao Li, Diqi Yang, Ke Ming, Shen Zhuang, Panpan Guo, Ruiling Yin, Jinrui Sun, Huikang Wang, Qianghui Lei, Zhenli Liu, Mingxing Ding, Xiaoshu Zhou, Yi Ding (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11585157.txt.
Description
Ma and colleagues traced a growth signal in twenty twenty-four that runs from gut microbes through the immune system to the liver. Shaping the gut with low doses of antibacterial agents had made young pigs and mice grow faster, and the team wanted to know why.
A gut microbe called Prevotella copri bloomed under the treatment. Its rise tipped gut immunity toward a helper cell type that releases a signal, IL-13, into the blood bound for the liver. In the liver, that signal switched on production of IGF-1, a powerful growth factor. Muscle then received more IGF-1 and built more of its own fibers. Each link in the chain was tested in turn, in animals and in cells. The authors say tuning gut immunity could become a strategy against poor growth in children and wasting in adults.
Catalog record
| CREATOR | Ning Ma, Haolong Wang, Qiuhua Li, Mengyu Chang, Jiandi Zhu, Sha Nan, Qiulin Zhang, Qiao Li, Diqi Yang, Ke Ming, Shen Zhuang, Panpan Guo, Ruiling Yin, Jinrui Sun, Huikang Wang, Qianghui Lei, Zhenli Liu, Mingxing Ding, Xiaoshu Zhou, Yi Ding |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |