TIMP1 regulates ferroptosis in osteoblasts by inhibiting TFRC ubiquitination: an in vitro and in vivo study
Bo Peng, Zhiwei Feng, Ao Yang, Jinmin Liu, Jinwen He, Lihu Xu, Cong Tian, Xiaoyun Sheng, Yaobin Wang, Rongjin Chen, Xingwen Wang, Xiaojun Ren, Bin Geng, Yayi Xia · 2024
Read TIMP1 regulates ferroptosis in osteoblasts by inhibiting TFRC ubiquitination: an in vitro and in vivo study by Bo Peng, Zhiwei Feng, Ao Yang, Jinmin Liu, Jinwen He, Lihu Xu, Cong Tian, Xiaoyun Sheng, Yaobin Wang, Rongjin Chen, Xingwen Wang, Xiaojun Ren, Bin Geng, Yayi Xia (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11585138.txt.
Description
Bo Peng and a large team study bone cell death in diabetes in this two thousand twenty-four paper. People with type 2 diabetes fracture bones more easily, though the reason is not fully clear. The team focused on ferroptosis, a form of cell death driven by iron and fat oxidation. They examined bone from diabetic mice and bone-forming cells stressed by high sugar and fat. A protein called TIMP1 emerged as a regulator.
TIMP1 protects a key iron-handling receptor from being tagged for disposal. That protection changes how much ferroptosis the bone cells suffer. The team confirmed the chain in cells and in animals. The finding names a possible route to protect diabetic bone. It may guide drugs that cut fracture risk in diabetes.
Catalog record
| CREATOR | Bo Peng, Zhiwei Feng, Ao Yang, Jinmin Liu, Jinwen He, Lihu Xu, Cong Tian, Xiaoyun Sheng, Yaobin Wang, Rongjin Chen, Xingwen Wang, Xiaojun Ren, Bin Geng, Yayi Xia |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |