The cell adhesion molecule CD44 acts as a modulator of 5-HT7 receptor functions
Saskia Borsdorf, Andre Zeug, Yuxin Wu, Elena Mitroshina, Maria Vedunova, Supriya A Gaitonde, Michel Bouvier, Michael C Wehr, Josephine Labus, Evgeni Ponimaskin · 2024
Read The cell adhesion molecule CD44 acts as a modulator of 5-HT7 receptor functions by Saskia Borsdorf, Andre Zeug, Yuxin Wu, Elena Mitroshina, Maria Vedunova, Supriya A Gaitonde, Michel Bouvier, Michael C Wehr, Josephine Labus, Evgeni Ponimaskin (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11585102.txt.
Description
Saskia Borsdorf and nine co-authors study how a sticky cell protein tunes a serotonin sensor in this twenty twenty-four paper. Serotonin helps set mood, and one of its receptors can pair up with other proteins. The team had found that this receptor binds CD44, a protein that helps cells cling and move.
Using light-based tests, they measured how eagerly the two bind, alone and paired. They then watched how pairing changed the receptor's signal output, with and without drugs that prod each partner. The results show CD44 acts as a dimmer for the receptor. Such tuning matters for how serotonin drugs may work in the brain.
Catalog record
| CREATOR | Saskia Borsdorf, Andre Zeug, Yuxin Wu, Elena Mitroshina, Maria Vedunova, Supriya A Gaitonde, Michel Bouvier, Michael C Wehr, Josephine Labus, Evgeni Ponimaskin |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |