Discovery of potential ferroptosis and osteoporosis biomarkers through TMT proteomics and bioinformatics analysis
Hui Su, Guoqing Tan, WenXuan Guo, Jin Sheng Yu, Zhanwang Xu, RuJie Zhuang, Haipeng Xue · 2024
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Description
Hui Su and co-authors hunted bone loss markers in a 2024 rat study. Osteoporosis thins bones after the ovaries stop, and a form of cell death driven by iron, called ferroptosis, may feed that loss. The team sought marker proteins that tie the two together.
They used a tagged protein read on bone from rats whose ovaries were removed, a standard model of the disease. Computer analysis then sorted which protein shifts line up with the iron-death path. Forty rats took part, half in the disease model arm. Named markers could guide early tests and new bone drugs.
Catalog record
| CREATOR | Hui Su, Guoqing Tan, WenXuan Guo, Jin Sheng Yu, Zhanwang Xu, RuJie Zhuang, Haipeng Xue |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 45 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |