Lysosomal “TRAP”: a neotype modality for clearance of viruses and variants
Chengliang Lyu, Zhanlong He, Xiaoming Hu, Shuang Wang, Meng Qin, Li Zhu, Yanyan Li, Fengmei Yang, Zhouguang Jiao, Xiao Zhang, Guihong Lu, Erqiang Wang, Yaling Hu, Yu Zhai, Youchun Wang, Weijin Huang, Dongshu Wang, Yimin Cui, Xiaocong Pang, Xiangzheng Liu, Hidehiro Kamiya, Guanghui Ma, Wei Wei · 2024
Read Lysosomal “TRAP”: a neotype modality for clearance of viruses and variants by Chengliang Lyu, Zhanlong He, Xiaoming Hu, Shuang Wang, Meng Qin, Li Zhu, Yanyan Li, Fengmei Yang, Zhouguang Jiao, Xiao Zhang, Guihong Lu, Erqiang Wang, Yaling Hu, Yu Zhai, Youchun Wang, Weijin Huang, Dongshu Wang, Yimin Cui, Xiaocong Pang, Xiangzheng Liu, Hidehiro Kamiya, Guanghui Ma, Wei Wei (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11584657.txt.
Description
Chengliang Lyu leads a large team in a 2024 paper on a lysosomal trap that clears viruses and their variants. A virus must first bind a host entry factor to get in. Immune cells called macrophages eat viruses and break them down in lysosomes, the cell's waste units, as a natural clear-out path.
The team took lysosomes from fired-up macrophages and fixed the virus entry protein ACE2 on them as bait. The trap then lures SARS-CoV-2 in, holds it, and breaks it down. Tests in cells, mice, hamsters, and human lung organoids show the trap clears the virus well.
Catalog record
| CREATOR | Chengliang Lyu, Zhanlong He, Xiaoming Hu, Shuang Wang, Meng Qin, Li Zhu, Yanyan Li, Fengmei Yang, Zhouguang Jiao, Xiao Zhang, Guihong Lu, Erqiang Wang, Yaling Hu, Yu Zhai, Youchun Wang, Weijin Huang, Dongshu Wang, Yimin Cui, Xiaocong Pang, Xiangzheng Liu, Hidehiro Kamiya, Guanghui Ma, Wei Wei |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 107 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |