TRPV4 activation by core body temperature has multimodal functions in the central nervous system
Koji Shibasaki · 2024
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Description
Koji Shibasaki reviewed in 2024 how a heat-sensing channel in the brain shapes thought and mood. Brain heat is held in a tight range, and the channel, called TRPV4, turns that heat into electric signals in nerve cells. It stays partly on at normal brain heat and lifts nerve firing. Mice bred without it show odd brain waves and low, withdrawn acts much like depression.
The channel also works in support cells and blood vessels of the brain, where it helps steer flow and care of tissue. Fever can push it out of tune. The review ties that misfire to epilepsy and to low mood after stress. Shibasaki frames brain heat as a true signal, not mere background.
Catalog record
| CREATOR | Koji Shibasaki |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 26 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |