Sex specific gut-microbiota signatures of resilient and comorbid gut-brain phenotypes induced by early life stress
Lars Wilmes, Valentina Caputi, Thomaz F.S. Bastiaanssen, James M. Collins, Fiona Crispie, Paul D. Cotter, Timothy G. Dinan, John F. Cryan, Gerard Clarke, Siobhain M. O'Mahony · 2024
Read Sex specific gut-microbiota signatures of resilient and comorbid gut-brain phenotypes induced by early life stress by Lars Wilmes, Valentina Caputi, Thomaz F.S. Bastiaanssen, James M. Collins, Fiona Crispie, Paul D. Cotter, Timothy G. Dinan, John F. Cryan, Gerard Clarke, Siobhain M. O'Mahony (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11582825.txt.
Description
Stress in the first days of life can echo in the gut and mind for years, and not the same way in each sex. Lars Wilmes and nine co-authors split rat pups from their mothers for hours a day in 2024 and tracked the fallout. Droppings taken before weaning gave gut germ maps and chemical reads. As grown rats, the pups faced gut pain tests and a swim test of low mood.
Four adult patterns came out: hale, pain-led, mood-led, and both ills at once. Each pattern's early gut germs already bore their own marks, in kinds, counts, and chemical paths. Male and female pups split along their own lines as well. The team say the seeds of later gut-brain ills sit in the early gut, and may one day be read or even steered there.
Catalog record
| CREATOR | Lars Wilmes, Valentina Caputi, Thomaz F.S. Bastiaanssen, James M. Collins, Fiona Crispie, Paul D. Cotter, Timothy G. Dinan, John F. Cryan, Gerard Clarke, Siobhain M. O'Mahony |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 79 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |