Targeting glycolysis for neuroprotection in early LPS-induced neuroinflammation
Adriana Fernanda K Vizuete, Fernanda Fróes, Marina Seady, Aline Castro Caurio, Osmar Vieira Ramires Junior, Ana Karla Oliveira Leite, Clarissa Penha Farias, Angela TS Wyse, Carlos-Alberto Gonçalves · 2024
Read Targeting glycolysis for neuroprotection in early LPS-induced neuroinflammation by Adriana Fernanda K Vizuete, Fernanda Fróes, Marina Seady, Aline Castro Caurio, Osmar Vieira Ramires Junior, Ana Karla Oliveira Leite, Clarissa Penha Farias, Angela TS Wyse, Carlos-Alberto Gonçalves (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11582448.txt.
Description
Adriana Vizuete and co-authors tested two drugs that might shield the brain during early inflammation, in a study published in 2024. Brain inflammation shifts immune cells toward a sugar-burning mode called aerobic glycolysis, which can harm neurons. The team triggered inflammation in animals with a bacterial toxin and watched the shift unfold. One drug dialed down the sugar burning, and the other blocked an inflammation sensor.
The sugar-blocking drug reversed the metabolic shift, calmed inflammation markers, and improved the animals' behavior. The sensor-blocking drug quieted a chain of inflammatory signals and lowered glucose uptake in the brain. Both results support the idea that the sugar-burning shift really occurs early in brain inflammation. The authors propose that tuning immune metabolism could become a route to protect the brain after injury.
Catalog record
| CREATOR | Adriana Fernanda K Vizuete, Fernanda Fróes, Marina Seady, Aline Castro Caurio, Osmar Vieira Ramires Junior, Ana Karla Oliveira Leite, Clarissa Penha Farias, Angela TS Wyse, Carlos-Alberto Gonçalves |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 47 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |