Systemic and transcriptional response to intermittent fasting and fasting-mimicking diet in mice
Helene Michenthaler, Kalina Duszka, Isabel Reinisch, Markus Galhuber, Elisabeth Moyschewitz, Sarah Stryeck, Tobias Madl, Andreas Prokesch, Jelena Krstic · 2024
Read Systemic and transcriptional response to intermittent fasting and fasting-mimicking diet in mice by Helene Michenthaler, Kalina Duszka, Isabel Reinisch, Markus Galhuber, Elisabeth Moyschewitz, Sarah Stryeck, Tobias Madl, Andreas Prokesch, Jelena Krstic (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11580389.txt.
Description
Helene Michenthaler and co-authors compare two fasting styles in mice, in a 2024 study. Intermittent fasting and a fasting-mimicking diet both cut calories in cycles, and both promise health gains. The team tracked whole-body signals and liver gene activity after short and long use of each.
Neither diet caused clear harm. Weight loss capped at 20 percent and bounced back on feeding days. The mimicking diet cut weight a bit more and drove stronger fasting signals in blood, such as ketones and a hormone named FGF21. Liver gene programs looked alike overall, though the mimicking diet pushed sugar-making and fat-burning genes harder at first. With repeated cycles, some of those gene responses dulled.
Catalog record
| CREATOR | Helene Michenthaler, Kalina Duszka, Isabel Reinisch, Markus Galhuber, Elisabeth Moyschewitz, Sarah Stryeck, Tobias Madl, Andreas Prokesch, Jelena Krstic |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |