High detection rate of circulating-tumor DNA from cerebrospinal fluid of children with central nervous system germ cell tumors
Yoshiko Nakano, Ian Burns, Liana Nobre, Robert Siddaway, Mansuba Rana, Cody Nesvick, Andrew Bondoc, Michelle Ku, Richard Yuditskiy, Dennis T L Ku, Matthew M K Shing, Kevin K F Cheng, Ho-Keung Ng, Anirban Das, Julie Bennett, Vijay Ramaswamy, Annie Huang, David Malkin, Birgit Ertl-Wagner, Peter Dirks, · 2024
Read High detection rate of circulating-tumor DNA from cerebrospinal fluid of children with central nervous system germ cell tumors by Yoshiko Nakano, Ian Burns, Liana Nobre, Robert Siddaway, Mansuba Rana, Cody Nesvick, Andrew Bondoc, Michelle Ku, Richard Yuditskiy, Dennis T L Ku, Matthew M K Shing, Kevin K F Cheng, Ho-Keung Ng, Anirban Das, Julie Bennett, Vijay Ramaswamy, Annie Huang, David Malkin, Birgit Ertl-Wagner, Peter Dirks, (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11580361.txt.
Description
Yoshiko Nakano, Ian Burns, Liana Nobre, and a large team detect childhood brain tumors from spinal fluid in this two thousand twenty-four paper. Central nervous system germ cell tumors strike adolescents, respond to treatment, but leave deficits, and biopsy carries risk. The team asked whether tumor DNA in cerebrospinal fluid could serve as a biomarker. They collected twenty-nine fluid samples from twenty-one patients and ran low-pass whole genome sequencing, reading copy-number alterations as measurable residual disease, alongside imaging and tumor markers.
At diagnosis, copy-number alterations were detected in samples from seventeen of nineteen patients, eighty-nine percent, including eight whose tumors were marker-negative by conventional tests. Samples taken during and after therapy suggested serial fluid analysis can track disease. The authors argue spinal fluid tumor DNA offers a high-yield, less invasive window on these tumors, guiding biopsy decisions and radiotherapy adaptation.
Catalog record
| CREATOR | Yoshiko Nakano, Ian Burns, Liana Nobre, Robert Siddaway, Mansuba Rana, Cody Nesvick, Andrew Bondoc, Michelle Ku, Richard Yuditskiy, Dennis T L Ku, Matthew M K Shing, Kevin K F Cheng, Ho-Keung Ng, Anirban Das, Julie Bennett, Vijay Ramaswamy, Annie Huang, David Malkin, Birgit Ertl-Wagner, Peter Dirks, |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |