Simultaneously quantifying a novel five-component anti- migraine formulation containing ergotamine, propyphenazone, caffeine, camylofin, and mecloxamine using UV spectrophotometry and chemometric models
Ahmed Emad F Abbas, Nahla A Abdelshafi, Mohammed Gamal, Michael K Halim, Basmat Amal M Said, Ibrahim A Naguib, Mohmeed M A Mansour, Samir Morshedy, Yomna A Salem · 2024
Read Simultaneously quantifying a novel five-component anti- migraine formulation containing ergotamine, propyphenazone, caffeine, camylofin, and mecloxamine using UV spectrophotometry and chemometric models by Ahmed Emad F Abbas, Nahla A Abdelshafi, Mohammed Gamal, Michael K Halim, Basmat Amal M Said, Ibrahim A Naguib, Mohmeed M A Mansour, Samir Morshedy, Yomna A Salem (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11580349.txt.
Description
Ahmed Abbas and co-authors present a lab method in 2024 for measuring all five ingredients of a migraine mixture at once with ultraviolet light. The five drugs sit at wildly different doses and their light spectra overlap heavily, which defeats simple tests. Three math models were compared for untangling the spectra. A careful scheme for splitting calibration data avoided biased checks.
One model, a curve-resolution method, recovered each ingredient within a few percent of truth. Its calibration and prediction errors were the smallest of the three. Six sustainability metrics rated the approach green, cheap, and practical. The authors pitch it for quality control of complex drug mixes.
Catalog record
| CREATOR | Ahmed Emad F Abbas, Nahla A Abdelshafi, Mohammed Gamal, Michael K Halim, Basmat Amal M Said, Ibrahim A Naguib, Mohmeed M A Mansour, Samir Morshedy, Yomna A Salem |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |