A pH-triggered self-releasing humic acid hydrogel loaded with porcine interferon α/γ achieves anti-pseudorabies virus effects by oral administration
Maoyuan Sun, Yongli Shi, Baishi Lei, Wuchao Zhang, Jingjing Feng, Shenghu Ge, Wanzhe Yuan, Kuan Zhao · 2024
Read A pH-triggered self-releasing humic acid hydrogel loaded with porcine interferon α/γ achieves anti-pseudorabies virus effects by oral administration by Maoyuan Sun, Yongli Shi, Baishi Lei, Wuchao Zhang, Jingjing Feng, Shenghu Ge, Wanzhe Yuan, Kuan Zhao (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11580204.txt.
Description
Maoyuan Sun and seven co-authors build a swallowable shield for antiviral proteins for pigs in a 2024 study. Interferons fight viruses and tune immunity, but shots are the only route since stomach acid wrecks them. The team fused two pig interferons into one protein to widen the punch.
They wrapped the fusion in a hydrogel made from humic acid that holds shut in acid and opens later. The gel's loose, honeycomb build soaked the protein up well. In lab dishes the fusion blocked two pig viruses with strong force, and neither gel nor protein harmed the cells. The work aims at farm-ready oral dosing.
Catalog record
| CREATOR | Maoyuan Sun, Yongli Shi, Baishi Lei, Wuchao Zhang, Jingjing Feng, Shenghu Ge, Wanzhe Yuan, Kuan Zhao |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |