Effectiveness and safety outcomes after long-term (54 weeks) vedolizumab therapy for Crohn’s disease: a prospective, real-world observational study including patient-reported outcomes (POLONEZ II)
Ariel Liebert, Maria Kłopocka, Agata Michalak, Halina Cichoz-Lach, Renata Talar-Wojnarowska, Danuta Domzał-Magrowska, Łukasz Konecki, Aleksandra Filipiuk, Michał Krogulecki, Maria Kopertowska-Majchrzak, Kamila Stawczyk-Eder, Katarzyna Waszak, Piotr Eder, Edyta Zagórowicz, Izabela Smoła, Krzysztof Wo · 2024
Read Effectiveness and safety outcomes after long-term (54 weeks) vedolizumab therapy for Crohn’s disease: a prospective, real-world observational study including patient-reported outcomes (POLONEZ II) by Ariel Liebert, Maria Kłopocka, Agata Michalak, Halina Cichoz-Lach, Renata Talar-Wojnarowska, Danuta Domzał-Magrowska, Łukasz Konecki, Aleksandra Filipiuk, Michał Krogulecki, Maria Kopertowska-Majchrzak, Kamila Stawczyk-Eder, Katarzyna Waszak, Piotr Eder, Edyta Zagórowicz, Izabela Smoła, Krzysztof Wo (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11580093.txt.
Description
Liebert and a large team reported real-world results in twenty twenty-four for vedolizumab, a drug for Crohn's disease, over fifty-four weeks. Crohn's disease causes lasting gut inflammation. The POLONEZ II study followed patients at ten centers in Poland in routine care, not a strict trial.
Ninety-eight patients with moderate to severe active disease took part. By week fifty-four, about sixty-three percent had a clinical response and forty-eight percent were in remission. About thirty-six percent were in remission without steroids. Patient reports of pain, stool frequency, fatigue, and quality of life all improved. Side effects were mostly mild, and hospital stays for Crohn's disease shortened. The authors conclude the drug kept working safely over the long term.
Catalog record
| CREATOR | Ariel Liebert, Maria Kłopocka, Agata Michalak, Halina Cichoz-Lach, Renata Talar-Wojnarowska, Danuta Domzał-Magrowska, Łukasz Konecki, Aleksandra Filipiuk, Michał Krogulecki, Maria Kopertowska-Majchrzak, Kamila Stawczyk-Eder, Katarzyna Waszak, Piotr Eder, Edyta Zagórowicz, Izabela Smoła, Krzysztof Wo |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |