The Impact of the Blood–Brain Barrier and Its Dysfunction in Parkinson’s Disease: Contributions to Pathogenesis and Progression
Muhammad Khalid Iqbal, Bakhtawar Khan, Hifsa, Ge YuXuan, Muhammad Mujahid, Mubin Mustafa Kiyani, Hamid Khan, Shahid Bashir · 2024
Read The Impact of the Blood–Brain Barrier and Its Dysfunction in Parkinson’s Disease: Contributions to Pathogenesis and Progression by Muhammad Khalid Iqbal, Bakhtawar Khan, Hifsa, Ge YuXuan, Muhammad Mujahid, Mubin Mustafa Kiyani, Hamid Khan, Shahid Bashir (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11579724.txt.
Description
Parkinson's disease kills the brain cells that make dopamine, and the blood brain barrier that should guard those cells weakens as the disease advances. Muhammad Khalid Iqbal and seven co-authors review in 2024 how that barrier's failure feeds the disease: stray molecules slip in, the protein alpha-synuclein clumps, and inflammation and oxidative stress take hold. A sister barrier in the eye fails alongside it.
Genetic and epigenetic shifts follow the breach, and the damage to DNA repair deepens the spiral. The authors argue that guarding synapses and the barrier could allow earlier diagnosis and slower progression. Patient grown midbrain cells offer truer models for testing such ideas. Personalized care built on a person's genetic form of the disease is their closing hope.
Catalog record
| CREATOR | Muhammad Khalid Iqbal, Bakhtawar Khan, Hifsa, Ge YuXuan, Muhammad Mujahid, Mubin Mustafa Kiyani, Hamid Khan, Shahid Bashir |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |