Potential Therapeutic Effect of Sinigrin on Diethylnitrosamine-Induced Liver Cancer in Mice: Exploring the Involvement of Nrf-2/HO-1, PI3K–Akt–mTOR Signaling Pathways, and Apoptosis
Zhe Bai, Hui Li, Baoping Jiao · 2024
Read Potential Therapeutic Effect of Sinigrin on Diethylnitrosamine-Induced Liver Cancer in Mice: Exploring the Involvement of Nrf-2/HO-1, PI3K–Akt–mTOR Signaling Pathways, and Apoptosis by Zhe Bai, Hui Li, Baoping Jiao (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11579720.txt.
Description
Zhe Bai, Hui Li, and Baoping Jiao test a mustard-family plant compound against chemically induced liver cancer in mice. The compound, sinigrin, occurs in Brassica plants and has drawn interest for anticancer effects. Tumors were triggered by injecting young mice with diethylnitrosamine; in the final four weeks of a ten-week study, treated mice received daily sinigrin by mouth at two doses.
Sinigrin shifted the blood picture toward health: liver enzymes and a tumor marker fell, while protein levels rose. It boosted the liver's own antioxidant enzymes and cut markers of oxidative damage. Levels of inflammatory signals dropped, and a growth-driving pathway chain, PI3K-Akt-mTOR, quieted down. At the same time the compound switched on the cell's internal death program, raising pro-death proteins and lowering their blockers. The authors conclude the protective effect works through antioxidant and pro-death actions together.
Catalog record
| CREATOR | Zhe Bai, Hui Li, Baoping Jiao |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |