pH-Dependent migratory behaviors of neutrophil-like cells in a microfluidic device with controllability of dissolved gas concentrations
Masashi Tomita, Satomi Hirose, Taishi Nakamura, Kenichi Funamoto · 2024
Read pH-Dependent migratory behaviors of neutrophil-like cells in a microfluidic device with controllability of dissolved gas concentrations by Masashi Tomita, Satomi Hirose, Taishi Nakamura, Kenichi Funamoto (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11579455.txt.
Description
Masashi Tomita and three co-authors study how acidity affects immune cell movement in a 2024 paper. Inflamed tissues often turn acidic as oxygen runs low and cells release acid waste. White blood cells gather in such spots, but how acidity itself steers them was unclear. The team built a tiny channel device that sets acidity by feeding gases at set strengths.
Their device held a smooth acidity slope across its channels. Seeded with neutrophil-like cells, it showed movement grew more active and faster at high acidity's opposite end, under alkaline conditions. Yet cells showed no directed drift along the slope over three hours. The device is offered as a tool for such studies.
Catalog record
| CREATOR | Masashi Tomita, Satomi Hirose, Taishi Nakamura, Kenichi Funamoto |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |