Evolutionary analysis of Hemagglutinin and neuraminidase gene variation in H1N1 swine influenza virus from vaccine intervention in China
Xinkun Zhao, Mingshuai Shen, Li Cui, Cun Liu, Jieshi Yu, Guisheng Wang, Mihajlo Erdeljan, Kezhou Wang, Shumin Chen, Zhao Wang · 2024
Read Evolutionary analysis of Hemagglutinin and neuraminidase gene variation in H1N1 swine influenza virus from vaccine intervention in China by Xinkun Zhao, Mingshuai Shen, Li Cui, Cun Liu, Jieshi Yu, Guisheng Wang, Mihajlo Erdeljan, Kezhou Wang, Shumin Chen, Zhao Wang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11579394.txt.
Description
Xinkun Zhao and co-authors track gene evolution in swine flu after vaccine rollout in China in a 2024 paper. Inactivated vaccines for pig influenza entered the Chinese market in twenty eighteen. Whether vaccine pressure speeds viral change in the two surface genes matters for future vaccine matching.
Gene pairs from three marketed vaccine strains were compared with field sequences over time. One surface gene evolved at a stable pace before vaccination, then changed much faster after rollout, with genetic distance jumping several fold. The second gene evolved smoothly throughout. Animal tests showed commercial vaccines weakly neutralized wild strains.
Catalog record
| CREATOR | Xinkun Zhao, Mingshuai Shen, Li Cui, Cun Liu, Jieshi Yu, Guisheng Wang, Mihajlo Erdeljan, Kezhou Wang, Shumin Chen, Zhao Wang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |