Divergent WNT signaling and drug sensitivity profiles within hepatoblastoma tumors and organoids
Thomas A Kluiver, Yuyan Lu, Stephanie A Schubert, Lianne J Kraaier, Femke Ringnalda, Philip Lijnzaad, Jeff DeMartino, Wouter L Megchelenbrink, Vicky Amo-Addae, Selma Eising, Flavia W de Faria, Daniel Münter, Marc van de Wetering, Kornelius Kerl, Evelien Duiker, Marius C van den Heuvel, Vincent E de · 2024
Read Divergent WNT signaling and drug sensitivity profiles within hepatoblastoma tumors and organoids by Thomas A Kluiver, Yuyan Lu, Stephanie A Schubert, Lianne J Kraaier, Femke Ringnalda, Philip Lijnzaad, Jeff DeMartino, Wouter L Megchelenbrink, Vicky Amo-Addae, Selma Eising, Flavia W de Faria, Daniel Münter, Marc van de Wetering, Kornelius Kerl, Evelien Duiker, Marius C van den Heuvel, Vincent E de (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11579375.txt.
Description
A child's liver cancer almost always switches on the same growth pathway, yet tumors behave very differently, and Thomas Kluiver and co-authors mapped that variety in a 2024 study of hepatoblastoma. They profiled tumors and lab-grown tumor organoids cell by cell, adding spatial mapping and drug screens.
Two epithelial signatures emerged. One looked fetal and liver-like, rich in the pathway's liver-specific targets and in regulators of bile and fat metabolism. The other looked embryonal, driven by the pathway's canonical targets. Two marker proteins cleanly separate the camps. Drug screens on the organoids then showed the camps answer treatments differently, opening a route to targeted therapy chosen by signature. The authors argue the split, visible only at single-cell resolution, explains much of the disease's puzzling variety.
Catalog record
| CREATOR | Thomas A Kluiver, Yuyan Lu, Stephanie A Schubert, Lianne J Kraaier, Femke Ringnalda, Philip Lijnzaad, Jeff DeMartino, Wouter L Megchelenbrink, Vicky Amo-Addae, Selma Eising, Flavia W de Faria, Daniel Münter, Marc van de Wetering, Kornelius Kerl, Evelien Duiker, Marius C van den Heuvel, Vincent E de |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 79 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |