Profiling CARD14 gene expression in Indian Psoriasis patients
S. Singh, D. Pradhan, P. Puri, Shruti Sharma, A. K. Jain · 2024
Read Profiling CARD14 gene expression in Indian Psoriasis patients by S. Singh, D. Pradhan, P. Puri, Shruti Sharma, A. K. Jain (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11579362.txt.
Description
Singh and four co-authors measured the activity of a gene called CARD14 in Indian patients with psoriasis, in a 2024 study. The gene acts as a scaffold in a signaling path that drives skin inflammation, and rare inherited changes in it cause a heritable form of the disease. Its role in common psoriasis in India was less clear.
The team compared 42 patients with moderate to severe plaque psoriasis against the same number of controls. Gene activity was read by a sensitive copying test and checked with tissue staining. Patient skin showed about twice the gene activity of control skin in the damaged areas. Staining placed the gene in vessel lining cells of the skin as well. The results match data from Western groups and tie the gene's overactivity to the Indian form of the disease.
Catalog record
| CREATOR | S. Singh, D. Pradhan, P. Puri, Shruti Sharma, A. K. Jain |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |