Transcription regulation of African swine fever virus: dual role of M1249L
Dongming Zhao, Nan Wang, Xiaoying Feng, Zhenjiang Zhang, Kongen Xu, Tao Zheng, Yunge Yang, Xuemei Li, Xianjin Ou, Rui Zhao, Zihe Rao, Zhigao Bu, Yutao Chen, Xiangxi Wang · 2024
Read Transcription regulation of African swine fever virus: dual role of M1249L by Dongming Zhao, Nan Wang, Xiaoying Feng, Zhenjiang Zhang, Kongen Xu, Tao Zheng, Yunge Yang, Xuemei Li, Xianjin Ou, Rui Zhao, Zihe Rao, Zhigao Bu, Yutao Chen, Xiangxi Wang (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11579359.txt.
Description
Dongming Zhao and co-authors uncover a dual role for one protein in African swine fever virus in a 2024 study. The virus carries its own transcription machinery, an eight-part polymerase plus helper factors, letting it copy genes inside many hosts. How that machinery is regulated over the infection cycle stayed murky.
The protein M1249L emerged as a central regulator. Early on, its tail domain acts like several temporary transcription factors, flipping activity on and off. Later it helps pack the machinery into new virus particles. Atomic structures of the polymerase bound to this protein show many shapes behind the switch. The findings open fresh drug target ideas.
Catalog record
| CREATOR | Dongming Zhao, Nan Wang, Xiaoying Feng, Zhenjiang Zhang, Kongen Xu, Tao Zheng, Yunge Yang, Xuemei Li, Xianjin Ou, Rui Zhao, Zihe Rao, Zhigao Bu, Yutao Chen, Xiangxi Wang |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 58 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |