Genetic variants associated with longevity in long-living Indians
Sandhya Kiran Pemmasani, Shakthiraju R G, Suraj V, Raunaq Bhattacharyya, Chetan Patel, Anil Kumar Gupta, Anuradha Acharya · 2024
Read Genetic variants associated with longevity in long-living Indians by Sandhya Kiran Pemmasani, Shakthiraju R G, Suraj V, Raunaq Bhattacharyya, Chetan Patel, Anil Kumar Gupta, Anuradha Acharya (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11579347.txt.
Description
Sandhya Kiran Pemmasani and co-authors search in 2024 for gene variants tied to long life in India. Genes play a real part in how long a person lives, but most studies have looked outside India. The team compared people aged eighty-five and up with younger adults, using a chip that tests many known disease-linked variants.
Nine variants stood out in the long-lived group. Some linked to a slower heart rate and lower risk of bone loss, anxiety, or schizophrenia ran higher in that group. Others tied to heart rhythm trouble and bile duct disease ran lower. A variant in a gene called FOXO3A, tied to long life in other countries, also showed up. Pathways for stress defense and energy use featured strongly.
Catalog record
| CREATOR | Sandhya Kiran Pemmasani, Shakthiraju R G, Suraj V, Raunaq Bhattacharyya, Chetan Patel, Anil Kumar Gupta, Anuradha Acharya |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 34 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |