Cell hiding in colorectal cancer: correlation with response to chemotherapy in vitro and in vivo
I Druzhkova, A Potapov, N Ignatova, M Bugrova, I Shchechkin, M Lukina, L Shimolina, E Kolesnikova, M Shirmanova, E Zagaynova · 2024
Read Cell hiding in colorectal cancer: correlation with response to chemotherapy in vitro and in vivo by I Druzhkova, A Potapov, N Ignatova, M Bugrova, I Shchechkin, M Lukina, L Shimolina, E Kolesnikova, M Shirmanova, E Zagaynova (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11579335.txt.
Description
Druzhkova and co-authors report cancer research from two thousand twenty-four on cells that hide inside other cells in colorectal cancer. In these cell-in-cell structures, an outer cell shields an inner one from a hostile setting. Such structures appear in many tumors, but their link to drug resistance was unclear.
Across five colorectal cancer cell lines, lines that formed these structures on their own were also the most drug resistant. After treatment with standard drug mixes, the structures grew more common in cultures and in tumors grown in animals. Inner cells were seen escaping once the drug was removed. Lines with acquired resistance held more structures than their drug-naive parents, and chromosome counts shifted as resistance developed.
Catalog record
| CREATOR | I Druzhkova, A Potapov, N Ignatova, M Bugrova, I Shchechkin, M Lukina, L Shimolina, E Kolesnikova, M Shirmanova, E Zagaynova |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |