Enhancing localized chemotherapy with anti-angiogenesis and nanomedicine synergy for improved tumor penetration in well-vascularized tumors
Mohammad Souri, Sohail Elahi, Farshad Moradi Kashkooli, Mohammad Kohandel, M. Soltani · 2024
Read Enhancing localized chemotherapy with anti-angiogenesis and nanomedicine synergy for improved tumor penetration in well-vascularized tumors by Mohammad Souri, Sohail Elahi, Farshad Moradi Kashkooli, Mohammad Kohandel, M. Soltani (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11579323.txt.
Description
Mohammad Souri and co-authors use a math model in 2024 to test a mixed plan for treating tumors that are rich in blood vessels. Drugs placed right into a tumor can work well, but blood flow washes them out fast in such tumors. That wash out caps how much good the drugs can do.
The plan pairs two tricks. Drugs that curb new blood vessel growth thin out the vessel web, which helps keep the treatment in place. Tiny drug loaded particles with a negative charge spread through the tumor tissue more fully. The model tracks drug flow and spread in the tumor under this mix. It shows how the two tricks work as a pair to push more drug deep into the tumor. The study is a model, not a patient trial, so it guides later lab and clinic tests.
Catalog record
| CREATOR | Mohammad Souri, Sohail Elahi, Farshad Moradi Kashkooli, Mohammad Kohandel, M. Soltani |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 198 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |