Androgen-targeted hsa_circ_0085121 encodes a novel protein and improves the development of prostate cancer through facilitating the activity of PI3K/Akt/mTOR pathway and enhancing AR-V7 alternative splicing
Jianfeng Li, Hui Qiu, Qingzhuo Dong, Hongyuan Yu, Chiyuan Piao, Zhengxiu Li, Yanbin Sun, Xiaolu Cui · 2024
Read Androgen-targeted hsa_circ_0085121 encodes a novel protein and improves the development of prostate cancer through facilitating the activity of PI3K/Akt/mTOR pathway and enhancing AR-V7 alternative splicing by Jianfeng Li, Hui Qiu, Qingzhuo Dong, Hongyuan Yu, Chiyuan Piao, Zhengxiu Li, Yanbin Sun, Xiaolu Cui (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11579034.txt.
Description
Jianfeng Li and colleagues report a two thousand twenty-four study of a circular RNA in prostate cancer. Prostate cancer is common and a leading cause of cancer death in men. The team searched tumour material for circular RNAs changed in cancer.
One molecule, circRNF19A, was raised in cancer cells and tumours. Surprisingly, it also builds a small protein of its own. Blocking the circular RNA slowed cancer cell growth, spread, and drug resistance. Its protein partner boosted hormone receptor activity and growth pathways. The work names a new possible target in a cancer that often escapes treatment.
Catalog record
| CREATOR | Jianfeng Li, Hui Qiu, Qingzhuo Dong, Hongyuan Yu, Chiyuan Piao, Zhengxiu Li, Yanbin Sun, Xiaolu Cui |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 104 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |