Identification of pancreatic cancer-specific protease substrates for protease-dependent targeted delivery
Etienne J. Slapak, Danny A. Zwijnenburg, Jan Koster, Maarten F. Bijlsma, C. Arnold Spek · 2024
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Description
Etienne Slapak and co-authors fish millions of peptides to find cut sites that only pancreatic cancer enzymes recognise, in work from twenty twenty-four. Pancreatic cancer drugs often poison the whole body before helping. Targeted carriers could release cargo only where cancer enzymes cut. The trick needs peptide links that healthy tissues leave untouched. A library of millions of peptide candidates starts the search.
Cancer cell juices enrich a small set of cuttable peptides strongly. A second screen against blood removes any peptide blood can cut. Most finalists cut cleanly across a panel of cancer cell lines. Healthy organ and blood samples largely spare the finalists. Several beat a known benchmark substrate on cancer specificity. Animal tests must still confirm the edge in living bodies. Protease-guided drug delivery gains sharper molecular scissors.
Catalog record
| CREATOR | Etienne J. Slapak, Danny A. Zwijnenburg, Jan Koster, Maarten F. Bijlsma, C. Arnold Spek |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |