Knockdown of the long noncoding RNA VSIG2-1:1 promotes the angiogenic ability of human pulmonary microvascular endothelial cells by activating the VEGF/PI3K/AKT pathway
Xiaoya Hu, Yihui Zheng, Mingchu Fang, Zhongjie Liang, Chao Wen, Jing Lin, Zhenlang Lin, Shangqin Chen · 2024
Read Knockdown of the long noncoding RNA VSIG2-1:1 promotes the angiogenic ability of human pulmonary microvascular endothelial cells by activating the VEGF/PI3K/AKT pathway by Xiaoya Hu, Yihui Zheng, Mingchu Fang, Zhongjie Liang, Chao Wen, Jing Lin, Zhenlang Lin, Shangqin Chen (2024) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-11577886.txt.
Description
Xiaoya Hu and seven co-authors study a long noncoding RNA in lung cells in a 2024 paper. The work bears on a lung disease of premature infants, where blood vessels grow poorly. Long RNA strands that do not build proteins can still guide cell behavior, but their roles here were unclear.
The team measured RNA levels in infants with and without the disease, then focused on one strand. Silencing that strand in vessel cells raised growth, movement, and tube formation. Boosting it had the reverse effect. The strand acts through a known growth pathway involving a vessel growth factor. The findings name a possible target for protecting infant lung vessels.
Catalog record
| CREATOR | Xiaoya Hu, Yihui Zheng, Mingchu Fang, Zhongjie Liang, Chao Wen, Jing Lin, Zhenlang Lin, Shangqin Chen |
|---|---|
| YEAR | 2024 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |